Sodium hydride → HCID 66756895, compound

Participants

Reaction Steps

To a solution of 5.59 g (20.0 mmol) of (R)-N-tert-butoxycarbonylalanine benzyl ester and 5.92 g (20.0 mmol) of dibenzyl fumarate in 60 mL of toluene was added 1.60 g (40 mmol) of 60% NaH in mineral oil. The reaction was stirred at ambient temperature under N2 for 24 h, then diluted with 300 mL of diethyl ether. The solution was extracted with 1M HCl(aq.) (1×50 mL), saturated NaHCO3(aq.) (3×50 mL), and brine (1×50 mL), dried over MgSO4, filtered, and concentrated to provide the titled compound as an oil.

Provenance & Evidence