2-Methylpropylenediamine → HCID 18460863, compound

HRID 855888Notes

Reaction equation

HRID 855888 reaction equation
[NH2:1][CH2:2][C:3]([NH2:6])([CH3:5])[CH3:4].Cl[C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][N:9]=1>>[NH2:6][C:3]([CH3:5])([CH3:4])[CH2:2][NH:1][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][N:9]=1

Participants

3

Reactant 2

HCID 131282-MethylpropylenediamineHCID 51520946-Chloro-3-pyridinecarbonitrile

Product 1

HCID 18460863HCID 18460863, compound

Conditions

Temperature
120 °C

Procedure

A mixture of 1,2-diamino-2-methylpropane (3.14 ml, 30 mmol), and 6-chloronicotinonitrile (2.77 g, 20 mmol) were heated to 120° C. for 2 days. The reaction mixture was filtered, and the inorganic salt was rinsed with EtOAc. The filterate was concentrated under reduced pressure to provide the titled compound as a pale yellow solid. MS (DCI) m/z 191 (M+H)+.

Workup

  1. filtrationThe reaction mixture was filtered
  2. washthe inorganic salt was rinsed with EtOAc
  3. concentrationThe filterate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ba0e0b34a91046e6811202e20ba6fd1f
Source dataset
uspto-grants-2007_08
Patent number
US07262207B2

Reaction notes

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