N,N-Dimethylaminoethyl chloride hydrochloride → HCID 11280634, compound

Participants

Reaction Steps

To a solution of 2-dimethylaminoethylchloride-hydrochloride (12 mmoles) in 50% sodium hydroxide (5 ml), benzyltriethylammonium chloride (0.65 mmole) and a solution of the alcohol 80 (1.1 mmole) in toluene (5 ml) were added. The reaction mixture was heated under vigorous stirring and refluxing for 3 hours. Then it was cooled to room temperature, diluted with water and extracted with dichloromethane. After purification by chromatography on a silica gel column, an oily product was isolated.

Provenance & Evidence