2-(5-Methoxy-2-methoxymethoxyphenyl)-4-methylbenzoxazole → 2-(2,5-Dimethoxyphenyl)-4-methylbenzoxazole

Participants

Reaction Steps

2-(2,5-dimethoxyphenyl)-4-methylbenzoxazole (F10) was prepared in a similar manner for the preparation of 2-(5-methoxy-2-methoxymethoxyphenyl)-4-methylbenzoxazole (F8) by using 2-[(2,5-dimethoxybenzylidene)amino]-3-methylphenol (F7) (5.43 g, 20 mmol) instead of 2-[(5-methoxy-2-methoxymethoxybenzylidene)amino]-3-methylphenol (F4) in 85% (4.55 g): 1H-NMR (500 MHz, CDCl3) δ3.53 (s, 3H), 5.24 (s, 3H), 7.17 (d, H, J=9.0 Hz), 7.35 (d, 1H, J=9.0 Hz), 10.52 (s, 1H).

Provenance & Evidence