2-(2-Bromoethoxy)tetrahydro-2H-pyran → HCID 23081638, compound

HRID 856021Notes

Reaction equation

HRID 856021 reaction equation
Cl.[F:2][C:3]([F:18])([F:17])[O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH:16]=2)=[CH:7][CH:6]=1.Br[CH2:20][CH2:21][O:22][CH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][O:24]1>>[O:24]1[CH2:25][CH2:26][CH2:27][CH2:28][CH:23]1[O:22][CH2:21][CH2:20][N:14]1[CH2:13][CH:12]=[C:11]([C:8]2[CH:9]=[CH:10][C:5]([O:4][C:3]([F:2])([F:17])[F:18])=[CH:6][CH:7]=2)[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyranHCID 23081381681508-64-5

Product 1

HCID 23081638HCID 23081638, compoundYield 47.1%

Procedure

Using 4-(4-trifluoromethoxyphenyl)-1,2,3,6-tetrahydropyridine monohydrochloride (680 mg, 2.43 mmol) and 2-(2-bromoethoxy)tetrahydropyran (610 mg, 2.92 mmol), 1-[2-(tetrahydropyran-2-yloxy)ethyl]-4-(4-trifluoromethoxyphenyl)-1,2,3,6-tetrahydropyridine (425 mg, yield 47%) as a pale brown oil was prepared in the same manner as described in Reference Example 15.

Sources & evidence

ORD record
ord-4cfc3c8a976348dc8f9b823adf789f63
Source dataset
uspto-grants-2007_08
Patent number
US07262212B2

Reaction notes

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