HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-(4-Trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine-1-carbonylchloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 4-[4-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine--hydrogen chloride (1/1) | HCID 21559979 | — |
| Product | 4-(4-Trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine-1-carbonylchloride | HCID 23081556 | 199.9% |
Reaction Steps
Using 4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride (300 mg, 1.14 mmol) prepared in Reference Example 97, pyridine (0.18 ml, 2.28 mmol) and triphosgene (112 mg, 0.38 mmol), 4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine-1-carbonylchloride (220 mg, yield 67%) as a yellow oil was prepared in the same manner as described in Reference Example 94.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07262212B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-2d9d68d454f5494b869d08b6969c1555 |
| Source note | uspto-grants-2007_08 |