反应详情

温度

60 °C

A mixture of (4-benzylpiperazin-1-yl)-(4-trifluoromethylphenyl)amine prepared in Reference Example 108 and 10% palladium/carbon (0.53 g) in ethanol (50 ml) was stirred at room temperature under an atmospheric pressure of hydrogen for 6 hours, and then at 60° C. for 10 hours. After the catalyst was removed by filtration through Celite, 10% palladium/carbon (0.53 g) was added to the filtrate, and the mixture was stirred at 60° C. under an atmospheric pressure of hydrogen for 8 hours. After the catalyst was removed by filtration through Celite, the filtrate was concentrated under reduced pressure. The resulting solid was dried in vacuo to afford piperazin-1-yl-(4-trifluoromethylphenyl)amine (1.76 g, yield 90%) as a colorless crystalline powder.

1. customAfter the catalyst was removed by filtration through Celite, 10% palladium/carbon (0.53 g)
2. additionwas added to the filtrate
3. customAfter the catalyst was removed by filtration through Celite
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe resulting solid was dried in vacuo