Sodium Hydroxide → HCID 23081599, compound

Participants

Reaction Steps

Lithium aluminum hydride (237 mg, 6.25 mmol) was suspended in THF (20 ml), which was stirred while cooling in an ice-bath. To which a solution of N-{2-[4-(4-trifluoromethylphenyl)piperazin-1-yl]ethyl}-formamide (942 mg, 3.13 mmol) prepared in Reference Example 155 in THF (10 ml) was added dropwise, and the mixture was stirred at room temperature for 2 hours and then heated under reflux for 2 hours. The reaction mixture was allowed to return to room temperature, to which water and a 15% sodium hydroxide aqueous solution were added carefully. To the mixture, sodium sulfate was added, and the resulting mixture was vigorously stirred and filtered through Celite. The filtrate was concentrated under reduced pressure to afford N-methyl-{2-[4-(4-trifluoromethylphenyl)piperazin-1-yl]ethyl}-amine (900 mg, yield 100%) as a yellow oil.

Provenance & Evidence