反应详情

Tert-butyl 4-(2-chloroethyl)piperazine-1-carboxylate (3.13 g, 12.58 mmol) was dissolved in methanol (20 ml), to which 40% methylamine methanol solution (30 ml) was added, and the mixture was heated under reflux for 5 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in methylene chloride. The mixture was washed with saturated sodium hydrogencarbonate aqueous solution. The organic layer was dried over magnesium sulfate, and then filtered, and the filtrate was concentrated under reduced pressure to afford tert-butyl 4-(2-methylaminoethyl)piperazine-1-carboxylate (3.0 g, yield 98%) as a pale yellow oil.

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureunder reflux for 5 hours
4. concentrationThe reaction mixture was concentrated under reduced pressure
5. dissolutionthe residue was dissolved in methylene chloride
6. washThe mixture was washed with saturated sodium hydrogencarbonate aqueous solution
7. dry with materialThe organic layer was dried over magnesium sulfate
8. filtrationfiltered
9. concentrationthe filtrate was concentrated under reduced pressure