Sodium hydride → HCID 69481241, compound

Participants

Reaction Steps

To the solution of (R)-3-(2-chloro-4-nitroimidazol-1-yl)-2-hydroxy-2-methylpropyl 5-chloro-2,3-dihydroindole-1-carboxylate prepared in Example 113 (0.60 g, 1.44 mmol) in DMF (6 ml), sodium hydride (70 mg, 1.73 mmol) was added followed by stirring 1 hour with cooling on ice-bath. To the reaction mixture, ice-water was added, and the precipitates were filtered off, washed with water and recrystallized from acetonitrile-isopropanol to afford (R)-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazol-2-ylmethyl 5-chloro-2,3-dihydroindole-1-carboxylate (0.30 g, yield 55%) as a white solid.

Provenance & Evidence