(R)-2-chloro-1-(2-methyloxiran-2-ylmethyl)-4-nitroimidazole → (S)-[l-(2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazol-2-ylmethyl)piperidin-4-yl]-(4-trifluoromethoxyphenyl)methanone

Participants

Reaction Steps

Using (R)-2-chloro-1-(2-methyloxiran-2-ylmethyl)-4-nitroimidazole prepared in Example 12 (1.0 g, 4.6 mmol) and 4-(4-trifluoromethoxybenzoyl)piperidine (1.3 g, 4.8 mmol) gave (S)-[l-(2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazol-2-ylmethyl)piperidin-4-yl]-(4-trifluoromethoxyphenyl)methanone (771 mg, yield 37%) as a light yellow powder.

Provenance & Evidence