反应详情

To a solution of 7-[4-(2-butoxyethoxy)phenyl]-1-propyl-N-[6-[(3-pyridinylmethyl)sulfanyl]-3-pyridinyl]-2,3-dihydro-1-benzazepine-4-carboxamide (0.91 g) in methylene chloride (27.3 ml) was added dropwise a solution of m-chloroperbenzoic acid (303 mg) in methylene chloride (18.2 ml) at −78° C., and the mixture was stirred for 15 minutes. To the reaction mixture was added an aqueous solution of saturated sodium thiosulfate. The mixture was extracted with ethyl acetate, and the organic layer was washed with saturated brine and dried over magnesium sulfate. The solvent was removed under reduced pressure, and the obtained residue was purified by silica gel column chromatography, to give 7-[4-(2-butoxyethoxy)phenyl]-1-propyl-N-[6-[(3-pyridinylmethyl)sulfinyl]-3-pyridinyl]-2,3-dihydro-1-benzazepine-4-carboxamide (Compound 274) (258 mg).

1. extractionThe mixture was extracted with ethyl acetate
2. washthe organic layer was washed with saturated brine
3. dry with materialdried over magnesium sulfate
4. customThe solvent was removed under reduced pressure
5. customthe obtained residue was purified by silica gel column chromatography