Hydrochloric Acid → HCID 69522544, compound

Participants

Reaction Steps

To a solution of [2-[[[4-[[[7-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-2,3-dihydro-1H-1-benzazepin-4-yl]carbonyl]amino]phenyl]sulfinyl]methyl]-1H-imidazol-1-yl]ethyl acetate (85 mg) in ethanol (5 ml) was added 1N aqueous solution of sodium hydroxide (0.14 ml) at room temperature. The mixture was stirred at room temperature for 1 hour, 1N hydrochloric acid (0.14 ml) was added to the mixture, and the mixture was concentrated under reduced pressure. To the residue was added 2-propanol, and the precipitated crystals were collected by filtration. The crystals were washed with 2-propanol and diisopropyl ether, to give [2-[[[4-[[[7-[4-(2-butoxyethoxy) phenyl]-1-isobutyl-2,3-dihydro-1H-1-benzazepin-4-yl]carbonyl]amino]phenyl]sulfinyl]methyl]-1H-imidazol-1-yl]acetic acid (Preparation of Compound 412) (65.7 mg) as yellow crystals.

Provenance & Evidence