HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Methoxy-4-nitrophenyl)(pyridin-2-yl)methanol → (4-Amino-2-methoxyphenyl)(pyridin-2-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Methoxy-4-nitrophenyl)(pyridin-2-yl)methanol | HCID 11196239 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (4-Amino-2-methoxyphenyl)(pyridin-2-yl)methanol | HCID 11264714 | 90.4% |
Reaction Steps
(2-methoxy-4-nitrophenyl)(pyridin-2-yl)methanol (0.5 g) was dissolved in ethyl acetate (25 ml), and the solution was reduced by catalytic hydrogenation overnight with 10% palladium-carbon of 50% hydration (50 mg). The catalyst was removed, and the solvent of the filtrate was distilled off to give (4-amino-2-methoxyphenyl)(pyridin-2-yl)methanol (0.4 g) as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07262185B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-169fdd20d3af497d87e514628c618490 |
| Source note | uspto-grants-2007_08 |