HCID 22938867, compound → HCID 22938900, compound

Participants

Reaction Steps

(2-methoxy-4-nitrophenyl)(4-methylpyridin-2-yl)methanol (2.2 g) was dissolved in ethyl acetate (50 ml) and ethanol (50 ml), and the solution was reduced by catalytic hydrogenation overnight with 10% palladium-carbon of 50% hydration (150 mg). The catalyst was removed, and the solvent of the filtrate was distilled off. The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane), to give (4-amino-2-methoxyphenyl)(4-methylpyridin-2-yl)methanol (0.65 g) as pale yellow crystals.

Provenance & Evidence