Ethanol → HCID 69522198, compound

Participants

Reaction Steps

2-(4-aminophenylthio)acetohydrazide (5 g) was suspended in ethanol (50 ml) and to the suspension was added 40% piruvaldehyde solution (6.8 ml), at room temperature, and the mixture was stirred for 20 minutes. 13% ammonia-ethanol solution (60 ml) was added to the mixture, and the mixture was heated for 4.5 hours at 150° C. The solvent was distilled off, and the residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane) to give 4-[(5-methyl-1,2,4-triazin-3-yl)methylthio]aniline (1.2 g) as colorless crystals.

Provenance & Evidence