HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-Amino-6-[(3-propylimidazol-4-yl)methylthio]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-(chloromethyl)-1-propyl-1H-imidazole hydrochloride | HCID 22938616 | — |
| Reactant | 6-aminopyridazine-3-thiol | HCID 178507803 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Amino-6-[(3-propylimidazol-4-yl)methylthio]pyridazine | HCID 69522719 | 65.6% |
Reaction Steps
3-amino-6-mercaptopyridazine (0.5 g), 4-chloromethyl-3-propylimidazole hydrochloride (0.62 g) and potassium carbonate (2.0 g) were added to N,N-dimethylformamide (10 ml), and the mixture was stirred overnight at room temperature. The solvent was distilled off, the residue was purified by basic silica gel column chromatography (elution solvent: methanol/ethyl acetate), to give 3-amino-6-[(3-propylimidazol-4-yl)methylthio]pyridazine (0.52 g) as yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07262185B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-326aa6da01b9404dbd49eeb93e9415a8 |
| Source note | uspto-grants-2007_08 |