反应详情

To 3-hydroxymethyl-4-propyl-4H-1,2,4-triazole (5.95 g), thionyl chloride (40 ml) was slowly added at 0° C. The mixture was heated to reflux for 1 hour, and concentrated under reduced pressure. To the residue was added ethanol, and the mixutre was further concentrated. To the residue were added ethyl acetate and small amount of ethanol, and the precipitated crystals were collected by filtration. The crystals were washed with ethyl acetate, to give 3-chloromethyl-4-propyl-4H-1,2,4-triazole hydrochloride (5.43 g) as pale yellow crystals.

1. temperatureThe mixture was heated
2. temperatureto reflux for 1 hour
3. concentrationconcentrated under reduced pressure
4. additionTo the residue was added ethanol
5. concentrationthe mixutre was further concentrated
6. additionTo the residue were added ethyl acetate and small amount of ethanol
7. filtrationthe precipitated crystals were collected by filtration
8. washThe crystals were washed with ethyl acetate