Chloroform → 497851-82-8

HRID 856652Notes

Reaction equation

HRID 856652 reaction equation
[CH2:1]([S:3][C:4]1[N:5]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:6](CO)=[N:7][N:8]=1)[CH3:2].[CH:15]([Cl:18])(Cl)[Cl:16]>S(Cl)(Cl)=O>[ClH:16].[Cl:18][CH2:15][C:6]1[N:5]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:4]([S:3][CH2:1][CH3:2])=[N:8][N:7]=1

Participants

4

Reactant 2

HCID 6212ChloroformHCID 22938543HCID 22938543, compound

Product 1

HCID 22938693497851-82-8

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

To a solution of 5-ethylthio-3-hydroxymethyl-4-isobutyl-4H-1,2,4-triazole (1.0 g) in chloroform (3 ml), thionyl chloride (8 ml) was slowly added at 0° C. The mixture was heated to reflux for 1 hour, and concentrated under reduced pressure. To the residue was added diethylether, and the precipitated crystals were collected by filtration. The crystals were washed with diethylether, to give 3-chloromethyl-5-ethylthio-4-isobutyl-4H-1,2,4-triazole hydrochloride (0.64 g) as colorless crystals.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 1 hour
  3. concentrationconcentrated under reduced pressure
  4. additionTo the residue was added diethylether
  5. filtrationthe precipitated crystals were collected by filtration
  6. washThe crystals were washed with diethylether

Sources & evidence

ORD record
ord-3e005e4993c146f4bcd35f9120be285e
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

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