Ethanol → HCID 69521968, compound

HRID 856655Notes

Reaction equation

HRID 856655 reaction equation
[N+:1]([C:4]1[CH:20]=[CH:19][C:7]([NH:8][CH:9](C)[C:10]2[N:14]([CH2:15][CH2:16][CH3:17])[CH:13]=[N:12][N:11]=2)=[CH:6][CH:5]=1)([O-])=O.[CH2:21](O)C>[Pd]>[CH3:21][N:8]([CH2:9][C:10]1[N:14]([CH2:15][CH2:16][CH3:17])[CH:13]=[N:12][N:11]=1)[C:7]1[CH:19]=[CH:20][C:4]([NH2:1])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 69522512HCID 69522512, compound

Product 1

HCID 69521968HCID 69521968, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 4-nitro[methyl(4-propyl-4H-1,2,4-triazol-3-ylmethyl)]aniline (1.0 g), and 10% Pd-C (0.3 g) in ethanol was stirred strongly for 18 hours under hydrogen atmosphere. Pd-C was removed by filtration, the reaction mixture was concentrated under reduced pressure, and the precipitated crystals were collected by filtration. The crystals were washed with diethylether, to give 4-[methyl(4-propyl-4H-1,2,4-triazol-3-ylmethyl)amino]aniline (0.50 g) as brown crystals.

Workup

  1. customPd-C was removed by filtration
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. filtrationthe precipitated crystals were collected by filtration
  4. washThe crystals were washed with diethylether

Sources & evidence

ORD record
ord-32b49990241c408e9929d75e30eec7e4
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

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