Methyl iodide → HCID 69521177, compound

Participants

Reaction Steps

To 5-[[(4-nitrophenyl)sulfanyl]methyl]-1,2,3,4-tetrazole (6.3 g) were added acetonitrile (315 ml), and then, to this solution was added potassium carbonate (4.5 g) and iodomethane (1.75 ml), and the mixture was stirred for 240 hours at room temperature. The solvent was removed under reduced pressure, and to the obtained residue was added ethyl acetate, and the organic layer was washed with water and saturated brine, and dried over magnesium sulfate. The solvent was removed under reduced pressure and the obtained residue was washed with hexane/ethyl acetate, to give 1-methyl-5-[[(4-nitrophenyl)sulfanyl]methyl]-1,2,3,4-tetrazole and 2-methyl-5-[[(4-nitrophenyl)sulfanyl]methyl]-1,2,3,4-tetrazole as mixture (3.87 g, 1:1).

Provenance & Evidence