Water → HCID 69521228, compound

Participants

Reaction Steps

4-nitro-2-(trifluoromethyl)benzenethiol (3.0 g) was dissolved in THF (60 ml), and to this solution was added triethylamine (5.25 ml) and then, 3-(chloromethyl)pyridine hydrochloride (2.65 g), and the mixture was stirred for 1 hour at room temperature. The reaction solution was added to water, and extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over magnesium sulfate. The solvent was removed under reduced pressure and the obtained residue was washed with hexane/ethyl acetate, to give 3-[[[4-nitro-2-(trifluoromethyl)phenyl]sulfanyl]methyl]pyridine (2.2 g).

Provenance & Evidence