Thionyl Chloride → 135206-93-8

HRID 856754Notes

Reaction equation

HRID 856754 reaction equation
O[CH2:2][C:3]1[N:4]([CH2:8][C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][N:7]=1.S(Cl)([Cl:15])=O>>[ClH:15].[Cl:15][CH2:2][C:3]1[N:4]([CH2:8][C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 22938562135206-92-7

Product 1

HCID 22938672135206-93-8

Conditions

Temperature
90 °C

Procedure

To 2-hydroxymethyl-1-(2,2,2-trifluoroethyl)imidazole (1.40 g) was added thionyl chloride (14 ml), and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature, the solvent was distilled off under reduced pressure and the obtained solid was washed with ethyl acetate, to give 2-chloromethyl-1-(2,2,2-trifluoroethyl)imidazole hydrochloride (1.63 g) as brown crystals.

Workup

  1. customto be at room temperature
  2. distillationthe solvent was distilled off under reduced pressure
  3. washthe obtained solid was washed with ethyl acetate

Sources & evidence

ORD record
ord-1b1df1f3a7874d369d3e8bc843ef27c9
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

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