Thionyl Chloride → HCID 22938404, compound

HRID 856757Notes

Reaction equation

HRID 856757 reaction equation
O[CH2:2][C:3]1[N:4]([CH2:8][CH:9]([CH3:11])[CH3:10])[CH:5]=[CH:6][N:7]=1.S(Cl)([Cl:14])=O>>[ClH:14].[Cl:14][CH2:2][C:3]1[N:4]([CH2:8][CH:9]([CH3:11])[CH3:10])[CH:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 22938481HCID 22938481, compound

Product 1

HCID 22938404HCID 22938404, compound

Conditions

Temperature
90 °C

Procedure

To 2-hydroxymethyl-1-isobutylimidazole (2.40 g) was added thionyl chloride (24 ml) at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure and the obtained residue was recrystallized from methanol-ethyl acetate, to give 2-chloromethyl-1-isobutylimidazole hydrochloride (2.17 g) as brown crystals.

Workup

  1. customto be at room temperature
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe obtained residue was recrystallized from methanol-ethyl acetate

Sources & evidence

ORD record
ord-beb181ef488346d596c9d2e1c204aed7
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

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