反应详情

温度

90 °C

To 5-hydroxymethyl-1-propylimidazole (33.0 g) was added by portions thionyl chloride (80 ml) at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure and the obtained residue was dissolved in methanol, and the solvent was distilled off again under reduced pressure. The obtained solid was recrystallized from ethyl acetate, to give 5-chloromethyl-1-propylimidazole hydrochloride (43.8 g) as colorless crystals.

1. customto be at room temperature
2. distillationThe solvent was distilled off under reduced pressure
3. dissolutionthe obtained residue was dissolved in methanol
4. distillationthe solvent was distilled off again under reduced pressure
5. customThe obtained solid was recrystallized from ethyl acetate