反应详情

To 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-3-yl methanol (1.0 g), thionyl chloride (5 ml) was added at 0° C. After heating to reflux for 40 minutes, the mixture was concentrated under reduced pressure. To the residue was added ethyl acetate, and the precipitated crystals were collected by filtration. The crystals were washed with ethyl acetate, to give 3-(chloromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine hydrochloride (1.03 g) as pale yellow crystals.

1. temperatureAfter heating
2. temperatureto reflux for 40 minutes
3. concentrationthe mixture was concentrated under reduced pressure
4. additionTo the residue was added ethyl acetate
5. filtrationthe precipitated crystals were collected by filtration
6. washThe crystals were washed with ethyl acetate