Thionyl Chloride → HCID 22938379, compound

Participants

Reaction Conditions

Reaction Steps

4-hydroxymethyl-5-methyl-1-propylimidazole (4.5 g) was added to thionyl chloride (25 ml) at 0° C., and the mixture was heated for 1 hour at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure and the obtained residue was dissolved in methanol, and the solvent was distilled off again under reduced pressure. The obtained residue was washed with ethyl acetate to give 4-chloromethyl-5-methyl-1-propylimidazole hydrochloride (5.79 g) as colorless crystals.

Provenance & Evidence