Hydrochloric Acid → HCID 131726125, compound

Participants

Reaction Steps

1-tert-Butyl 4-(4-{[(4-methylphenyl)sulfonyl]amino}-1-naphthyl)-1-piperazinecarboxylate (intermediate 10) (0.4 g, 0.8 mmol) was dissolved in THF (20 mL) and treated with a 1N solution of HCl in diethyl ether (30 mL) for twelve hours. The product was collected as a pale pink solid. Yield 0.2 g (60%). mp 181° C. (dec); 1H NMR (DMSO-d6) δ 2.80 (s, 3 H), 3.1 (br, 4 H), 3.3 (br, 4 H), 7.00 (q, J=8.06 Hz, 2 H), 7.27 (ab, J=8.30 Hz, 2 H), 7.4–7.5 (m, 2 H), 7.53 (ab, J=8.30 Hz, 2 H), 7.99 (d, J=8.06 Hz, 1 H), 8.07 (d, J=7.57 Hz, 1 H), 9.2 (br, 2 H); MS (ESI+) for C21 H23 N3 O2 S Found m/z 381.1499 M+. Calc. 381.1611.

Provenance & Evidence