3,4-Dimethoxybenzenesulfonyl chloride → HCID 131726130, compound

HRID 856918Notes

Reaction equation

HRID 856918 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([N:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH:14]([CH3:25])[CH2:13]2)=[CH:4][CH:3]=1.[CH3:26][O:27][C:28]1[CH:29]=[C:30]([S:36]([Cl:39])(=[O:38])=[O:37])[CH:31]=[CH:32][C:33]=1[O:34][CH3:35]>>[ClH:39].[CH3:26][O:27][C:28]1[CH:29]=[C:30]([S:36]([NH:1][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]([N:12]3[CH2:17][CH2:16][NH:15][CH:14]([CH3:25])[CH2:13]3)=[CH:4][CH:3]=2)(=[O:37])=[O:38])[CH:31]=[CH:32][C:33]=1[O:34][CH3:35]

Participants

3

Reactant 2

HCID 27341833,4-Dimethoxybenzenesulfonyl chlorideHCID 21864872HCID 21864872, compound2×

Product 1

HCID 131726130HCID 131726130, compound

Procedure

The title compound was prepared from (intermediate 8 after reduction according to Method A) tert-butyl 4-(4-amino-1-naphthyl)-2-methyl-1-piperazinecarboxylate (0.189 g, 0.55 mmol) and 3,4-dimethoxybenzenesulfonyl chloride (0.130 g, 0.55 mmol) by the method described above: yield HCl-salt 0.068 g (26%); 1H NMR (CD3OD)

Sources & evidence

ORD record
ord-604a59698f1b4437bba742667502a56e
Source dataset
uspto-grants-2006_12
Patent number
US07144883B2

Reaction notes

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