Pyridine → HCID 131726135, compound

Participants

Reaction Steps

To a solution of 4-(4-isopropyl-1-piperazinyl)-1-naphthylamine (0.209 g, 0.776 mmol) (prepared according to Methods A and B) and pyridine (438 μL, 5.43 mmol) in CH2Cl2 (3.0 mL) was added 4-methylbenzenesulfonyl chloride (0.163 g, 0.850 mmol) in CH2Cl2 (1.0 mL). The solution was stirred at room temperature for 16 hours and the solid was collected by filtration as the HCl-salt to yield 0.236 g (66%); 1H NMR (DMSO-d6) δ 10.65 (br s, 1H), 9.95 (br s, 1H), 8.10–8.05 (m, 1H), 8.02–7.94 (m, 1H), 7.56–7.49 (m, 2H), 7.48–7.37 (m, 2H), 7.28–7.22 (m, 2H), 7.02–6.94 (m, 2H), 3.53–3.40 (m, 3H), 3.37–3.15 (m, 8H), 2.28 (s, 3H), 1.32–1.28 (m, 6H); MS (posES-FIA) m/z=423.1972 (M+H)(calc 423.1980).

Provenance & Evidence