Hydrochloric Acid → 3-Hydroxy-5,6-dihydro-naphthalene-2-carbonitrile

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To the suspension of 3-hydroxy-8-oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile from (150 mg, 0.8 mmol) in 2 mL anhydrous THF was added 2M LiBH4 in THF (0.6 mL, 1.2 mmol, 1.5 eq) and 0.5 mL anhydrous methanol. The reaction was shaken at 40° C. for 2 h. To this was added 5 mL water and some 1N HCl until pH=2. The mixture was extracted with ethyl acetate 3 times and dried down with genavac at high temperature. The resulting dark liquid (about 100 mg) was used directly in the next step reaction.

Herkunft & Nachweise