(3-Amino-6-iodo-1-benzofuran-2-yl)(2,4-dichlorophenyl)methanone → (3-Amino-8-benzyl-5,6,7,8-tetrahydro-furo[3,2-g]quinolin-2-yl)-(2,4-dichloro-phenyl)methanone

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Reaction Steps

This compound was prepared from 1-benzyl-7-hydroxy-1,2,3,4-tetrahydro-quinoline-6-carbonitrile (20 mg, 0.08 mmol) from step 4 in the manner described for [(3-amino-6-iodo-benzofuran-2-yl)-(2,4-dichloro-phenyl)-methanone, affording 10 mg (29%) of the title compound as a yellow solid. 1H-NMR (CDCl3) δ 7.44–7.40 (m, 2H), 7.33–7.22 (m, 4H), 7.18 (s, 1H), 7.15–7.13 (m, 2H), 6.25 (s, 1H), 5.96 (bs, 2H), 4.52 (s, 2H), 3.47 (t, J=6.0 Hz, 2H), 2.89 (t, J=5.9 Hz, 2H), 2.03 (m, 2H); MS LC-MS (MH+=451.3), LC MS RT: 3.81 min.

Provenance & Evidence