HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(4-Chloro-phenyl)-cyclopropanecarboxylic acid[1-(2,3-dihydro-benzofuran-5-yl)-ethyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(4-Chlorophenyl)cyclopropanecarboxylic acid | HCID 237412 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-(2,3-Dihydro-1-benzofuran-5-yl)ethan-1-amine | HCID 16768433 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-Chloro-phenyl)-cyclopropanecarboxylic acid[1-(2,3-dihydro-benzofuran-5-yl)-ethyl]-amide | HCID 21864679 | 67.3% |
Reaction Steps
A mixture of 1-(2,3-dihydro-benzofuran-5-yl)-ethylamine (0.1 mmol), 2-(4-Chloro-phenyl)-cyclopropanecarboxylic acid (0.1 mmol), EDAC.HCl (0.2 mmol), DMAP (0.2 mmol), and triethylamine (0.4 mmol) in dichloromethane (2 mL) was stirred at room temperature overnight. The reaction mixture was purified by flash chromatography eluting with 50% hexanes in ethyl acetate to give the title compound (23 mg) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07144881B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-b6d9a95b08cf494c8c565a162455954c |
| Source note | uspto-grants-2006_12 |