HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 857093Generated: October 28, 2026
Sodium Azide → 2-Azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone
https://huagongshe.com/reaction/857093
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)- | HCID 11150315 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone | HCID 11402365 | 86.7% |
Reaction Steps
2-Bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone (Glaxo DE 3513885, 1985) (52 g) in DMF (300 ml) was treated with sodium azide (12.24 g) and the mixture was stirred for 2 h at 20° C. The reaction mixture was diluted with EtOAc and washed with water and dried (MgSO4). The solvent was removed under reduced pressure to give the title compound (39.11 g). TSP+ve 248(MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07144908B2 |
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| Source dataset | uspto-grants-2006_12 |
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| ORD ID | ord-1df0b99e5cde456db86eaf48cb22a57e |
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| Source note | uspto-grants-2006_12 |
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