Dimethyl Sulfate → HCID 21867082, compound

HRID 857127Notes

Reaction equation

HRID 857127 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][C:11](=[O:13])[NH:10][C:9]2=[O:14])[CH:5]=[CH:6][CH:7]=1.[OH-].[K+].S(OC)(O[CH3:21])(=O)=O>O>[I:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][C:11](=[O:13])[N:10]([CH3:21])[C:9]2=[O:14])[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 14797Potassium HydroxideHCID 218671771-(3-Iodophenyl)-2,4-imidazolidinedione

Product 1

HCID 21867082HCID 21867082, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-(3-Iodophenyl)imidazolidine-2,4-dione (0.588 g) was suspended in water (13 ml) and treated with potassium hydroxide (0.37 g). The reaction was placed in a warming bath (45° C.) and treated with dimethyl sulfate (0.784 ml). After stirring for 4 h the reaction mixture was chilled and filtered. The cake was washed with water and dried to give the title compound (0.381 g). LCMS RT=2.94 min.

Workup

  1. customThe reaction was placed in a warming bath
  2. temperaturewas chilled
  3. filtrationfiltered
  4. washThe cake was washed with water
  5. customdried

Sources & evidence

ORD record
ord-4fbf68c3560c4f87bed139a7a511c906
Source dataset
uspto-grants-2006_12
Patent number
US07144908B2

Reaction notes

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