Water → HCID 21867233, compound

Participants

Reaction Conditions

Reaction Steps

Methyl[3,5-dibromo-4-(4-methoxy-3-iodophenoxy)phenyl]acetate (0.82 g, 1.5 mmol) was dissolved in dichloromethane (25 mL) and cooled down to −78° C. Boron tribromide (8.8 mL, 1 N in dichloromethane) was added and the reaction mixture was stirred at −20° C. for 30 hours. Water was added to the reaction mixture, the organic phase separated and concentrated. The residue was filtered on a short column (silica, dichloromethane/ethyl acetate 1:1), to give 0.73 g (90%) of methyl [3,5-dibromo-4-(4-hydroxy-3-iodophenoxy)-phenyl]acetate as a beige solid mass.

Provenance & Evidence