Ammonia → HCID 21867239, compound

Participants

Reaction Steps

To methyl [3,5-dibromo-4-(4-methoxy-3-nitrophenoxy)phenyl]acetate (5 g), dissolved in 2-(2-methoxyethoxy)ethanol (50 mL) was added an aqueous solution of ammonia (32%, 7 mL). The reaction mixture was heated at 150° C. for, with continuos refill of ammonia. After 24 hours, water was added followed by an aqueous solution of hydrochloric acid. This was continued until the acidity of the solution reached pH 2. The aqueous phase was extracted with chloroform, washed with brine and dried over magnesium sulphate. After concentration of the organic phase, 4.1 g (84%) of methyl [3,5-dibromo-4-(4-amino-3-nitrophenoxy)phenyl]acetate was obtained as an yellow solid mass.

Provenance & Evidence