Hydrochloric Acid → HCID 86592822, compound

Participants

Reaction Steps

Methyl[3,5-dibromo-4-(4-amino-3-nitrophenoxy)phenyl]acetate (1.1 g, Example 2(b)) was treated with sodium dithionite as described in Example 2(c). The formed methyl [3,5-dibromo-4-(3,4-diaminophenoxy)phenyl]acetate was dissolved in methanol (36 mL). An aqueous solution of hydrochloric acid (35%, 2.1 mL) was added, followed by acetylacetone (0.48 g). The reaction mixture was refluxed for 5.5 hours, cooled down and the formed yellow precipitate was filtered off. After recrystallisation from ethanol, 80 mg (5%) of methyl [3,5-dibromo-4-(2-methyl-5-benzoimidazolyloxy)phenyl]acetate was obtained.

Provenance & Evidence