HRID857180

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10796

Cesium carbonate

CCs2O3

HCID4142526

tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

C11H20N2O2

结构：COc1ccc(OC(CCCOS(C)(=O)=O)c2ccc(C#N)cc2)cc1OC

HCID21867568

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(OC(CCCN2CC3CN(C(=O)OC(C)(C)C)CC3C2)c2ccc(C#N)cc2)cc1OC

HCID21867606

未命名化合物

收率 60%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

4-(4-Cyanophenyl)-4-(3,4-dimethoxyphenoxy)butyl methanesulfonate (1.12 g, 2.8 mmol; see step (c) above), tert-butyl hexahydropyrrolo[3,4-c]-pyrrole-2(1H)-carboxylate (0.59 g, 2.8 mmol; see Preparation A above) and Cs2CO3 were mixed in CH3CN (30 mL) and stirred at rt for 3 days. The mixture was then filtered and evaporated. Purification on silica (ethyl acetate:MeOH (9:1) eluant) gave 0.9 g (60%) of the sub-title compound.

WORKUP

后处理

filtrationThe mixture was then filtered
customevaporated
customPurification on silica (ethyl acetate:MeOH (9:1) eluant)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0c6dcbbebff2421d8459d31370f1e382
来源数据集: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07144914B2
来源说明: uspto-grants-2006_12

反应 SMILES

CS(O[CH2:6][CH2:7][CH2:8][CH:9]([C:21]1[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[CH:23][CH:22]=1)[O:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)(=O)=O.[CH2:29]1[CH:33]2[CH2:34][NH:35][CH2:36][CH:32]2[CH2:31][N:30]1[C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38].C([O-])([O-])=O.[Cs+].[Cs+]>CC#N>[C:27]([C:24]1[CH:23]=[CH:22][C:21]([CH:9]([O:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=2)[CH2:8][CH2:7][CH2:6][N:35]2[CH2:34][CH:33]3[CH2:29][N:30]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH2:31][CH:32]3[CH2:36]2)=[CH:26][CH:25]=1)#[N:28]