HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 857182Generated: October 26, 2026
Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylate → tert-Butyl 5-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
https://huagongshe.com/reaction/857182
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylate | HCID 4142526 | — |
| Reactant | (S)-4-(Oxiran-2-ylmethoxy)benzonitrile | HCID 6934187 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | tert-Butyl 5-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate | HCID 69662614 | — |
Reaction Steps
4-[(2S)-Oxiranylmethoxy]benzonitrile (4.36 g, 0.025 mol; prepared as described in International Patent Application WO 99/31100) and tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (6.2 g, 0.025 mol; see Preparation A above) were mixed in isopropanol and stirred at 60° C. overnight. The solvent was evaporated and the product was purified by flash chromatography on silica, eluting with ethyl acetate, 10% MeOH. This gave 1.2 g (88%) of the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07144914B2 |
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| Source dataset | uspto-grants-2006_12 |
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| ORD ID | ord-2036e5b00be548eb9b0770fa656cf707 |
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| Source note | uspto-grants-2006_12 |
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