3-Amino-1-propanol → 4-((3-Hydroxypropyl)amino)benzonitrile

HRID 857183노트

반응식

HRID 857183 반응식
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[NH2:10][CH2:11][CH2:12][CH2:13][OH:14]>O>[OH:14][CH2:13][CH2:12][CH2:11][NH:10][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 90863-Amino-1-propanolHCID 145174-Fluorobenzonitrile

생성물 1

HCID 218676634-((3-Hydroxypropyl)amino)benzonitrile수율 97.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 4-fluorobenzonitrile (12.0 g, 99.1 mmol) and 3-amino-1-propanol (59.6 g, 793 mmol) was stirred at 80° C. under an inert atmosphere for 3 hours before water (150 mL) was added. The mixture was allowed to cool to rt, and was then extracted with diethyl ether. The organic layer was separated, dried (Na2SO4), filtered and concentrated in vacuo to yield 17 g (97%) of the title compound as an oil that crystallised upon standing.

후처리

  1. additionwas added
  2. extractionwas then extracted with diethyl ether
  3. customThe organic layer was separated
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-e1d1509384c24951b7a35fdfe2761386
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144914B2

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