HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,3-Dibromopropane → 4-[(3-Bromopropyl)sulfanyl]benzonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,3-Dibromopropane | HCID 8001 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 4-Thiobenzonitrile | HCID 585058 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 4-[(3-Bromopropyl)sulfanyl]benzonitrile | HCID 21867671 | 62,1% |
Reaktionsschritte
A mixture of 4-cyanothiophenol (20.8 g, 154 mmol), 1,3-dibromopropane (155 g, 0.77 mol) and K2CO3 (21.3 g, 154 mmol) in MeCN (300 mL) was refluxed overnight. Filtration and evaporation of the solvent gave a brown oil that crystallised when treated with EtOH. The crystals were isolated by filtration to give the sub-title compound (24.5 g, 62%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07144914B2 |
| Quelldatensatz | uspto-grants-2006_12 |
| ORD ID | ord-a846d75cc5364823b7042d00c385c354 |
| Quellennotiz | uspto-grants-2006_12 |