HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 69662353, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetone Cyanohydrin | HCID 6406 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 69662353 | HCID 69662353 | 50% |
Reaction Steps
A mixture of 1,1′-carbonyldiimidazole (5 g, 31 mmol) and 2-hydroxy-2-methylpropanenitrile (2.6 g, 31 mmol) in DCM was stirred at rt overnight. Water was added and the organic layer was separated, dried (Na2SO4) and concentrated in vacuo. The resulting residue was purified by chromatography on silica gel, eluting with ethyl acetate, to give 2.7 g (50%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07144914B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-b590b42fa49e4334a369a874c8a4739d |
| Source note | uspto-grants-2006_12 |