1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine

HRID 857191Notes

Reaction equation

HRID 857191 reaction equation
[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[OH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][N:4]([C:10](=[O:12])[CH3:11])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 7918Acetic Anhydride

Product 1

HCID 47396291-Acetyl-4-(2-hydroxyethyl)piperazineYield 65%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g, 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.

Workup

  1. additionadded dropwise
  2. additionDuring addition
  3. customrose from 22 to 60° C
  4. customThe reaction mixture was evaporated several times with toluene

Sources & evidence

ORD record
ord-54b2e0586fcb4860b86cd523563eb2b4
Source dataset
uspto-grants-2006_12
Patent number
US07144914B2

Reaction notes

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