反应详情

温度

100 °C

10.09 g (66.84 mmol) of 2-bromomalonaldehyde are added to a solution of 15.00 g (55.70 mmol) of 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide (example I, step 5) in 200 ml of glacial acetic acid and stirring at 100° C. for 2 hours. The solvent is removed in vacuo. The residue is purified by chromatography on silica gel (eluent: DCM/methanol 40:1 to 30:1). 9.51 g (44% of theory) of the product are obtained.

1. customThe solvent is removed in vacuo
2. customThe residue is purified by chromatography on silica gel (eluent: DCM/methanol 40:1 to 30:1)
3. custom9.51 g (44% of theory) of the product are obtained