HCID 21866891, compound → HCID 21866851, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 2-methyl-2-[6-(tetrahydro-2H-pyran-2-yloxy)-4-hexynyloxy]propionate (3.72 g) was dissolved in 37 ml of ethanol, and 15.372 mg of Amberlyst® was added thereto and the mixture was stirred for 1 hour at 55-60° C. After cooling, the mixture was filtrated and the filtrate was concentrated. The residue was purified by silica gel column chromatography (Wakogel® C-200, n-hexane: ethyl acetate=9:1-3:1) to provide 1.98 g of the objective compound as pale yellow oil.

Provenance & Evidence