Sodium Hydroxide → HCID 23706078, compound

HRID 857240Notes

Reaction equation

HRID 857240 reaction equation
[C:1]1([C:6]([NH:8][CH2:9][C:10]([O:12]C)=[O:11])=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+:15]>CO>[C:1]1([C:6]([NH:8][CH2:9][C:10]([O-:12])=[O:11])=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.[Na+:15]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 531395HCID 531395, compound

Product 1

HCID 23706078HCID 23706078, compoundYield 103.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 200 ml of a solution of 16.70 g of methyl 2-(2-thenoylamino)acetate in methanol, 20 ml of aqueous solution of 4.02 g sodium hydroxide was added, and heated to reflux for 30 minutes. The solvent was distilled off under reduced pressure. The residue was crystallized by addition of isopropanol to provide 18.03 g of the objective compound as pale yellow crystals.

Workup

  1. temperatureheated
  2. temperatureto reflux for 30 minutes
  3. distillationThe solvent was distilled off under reduced pressure
  4. customThe residue was crystallized by addition of isopropanol

Sources & evidence

ORD record
ord-a8b25ec6c21c40719c28098fed0f32f4
Source dataset
uspto-grants-2006_12
Patent number
US07144906B2

Reaction notes

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