1,4-Dioxane hydrochloride → HCID 68607749, compound

Participants

Reaction Steps

A 50 ml round bottom flask was charged with 1-benzyl (1S)-1-[({(1S,2R)-1-benzyl-3-[(tert-butoxycarbonyl)(3-methoxybenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-4-oxo-4-(1-piperidinyl)butylcarbamate (XXXVI, EXAMPLE 3, 100 mg) in dioxane/hydrochloric acid (4 N, 4 ml). The reaction is stirred 15 minutes when HPLC analysis indicates complete de-protection. The reaction mixture is concentrated under reduced pressure. The crude product is chased with acetonitrile (5 ml) then methylene chloride (5 ml). The resulting hydrochloride salt is dried under reduced pressure, to give the title compound, M+H=631.

Provenance & Evidence