HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 6-(4-Pyridylmethyl)-8-(3-nitrophenyl)quinoline | HCID 9819356 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Quinoline | HCID 7047 | — |
Reaction Steps
To a solution of the 8-(3-nitro-phenyl)-6-pyridin-4-ylmethyl-quinoline (1.0 eq) described in Step 1 in EtOH (0.2M) at 60° C. was added of water (final concentration 0.15M) and saturated aqueous NH4Cl (1.3 eq) followed by iron (12 eq). The final mixture was stirred at 60° C. for 2 h, cooled to room temperature, filtered on celite and concentrated to afford the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07144896B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-c20e2479fed5484581f295c73f5418af |
| Source note | uspto-grants-2006_12 |