反应详情

To a solution of (4-methylsulfanyl-phenyl)-oxo-acetic acid ethyl ester (Described in J. Med. Chem. 1981, 407) (1.0 eq) in EtOH (0.22M) at −78° C. was added NaBH4 (0.5 eq). The resulting mixture was stirred for 30 min then quenched at −78° C. by adding saturated aqueous NH4Cl. The residual mixture was concentrated, filtered on silica gel using EtOAc. The combined organic extracts were concentrated and the residual solid was recrystallised in Et2O/Hex to afford the desired compound as a yellow solid.

1. customthen quenched at −78° C.
2. additionby adding saturated aqueous NH4Cl
3. concentrationThe residual mixture was concentrated
4. filtrationfiltered on silica gel
5. concentrationThe combined organic extracts were concentrated
6. customthe residual solid was recrystallised in Et2O/Hex